Female infertility is a common and devastating condition with life-long health, emotional and social consequences. There is currently no pharmacological therapy for preserving oocyte quality during aging, which is the strongest risk factor for infertility. This leads to an age dependent decline in natural conception and IVF success rates. Here, we show that this is due in part to declining levels of the metabolic cofactor nicotinamide adenine dinucleotide (NAD+), and that restoring NAD+ levels with its metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality and quantity in aged animals, leading to improved fertility
Emerging research shows that increased Nicotinamide Adenine Dinucleotide (NAD+) levels may slow the aging process or even reverse it. NAD+ can also delay the progression of age-related diseases—making it a powerful tool to stay active throughout your lifetime.
WHAT IS NAD+?
NAD+ is a molecule naturally found in every cell in the body. It enables mitochondria to produce energy for your body’s cells to sustain all its necessary functions. Certain proteins called sirtuins that are present in your cells also need NAD+ to function properly and regulate cellular health.
Research shows that as we age, our levels of NAD+ decline. This leaves us at great risk for muscular degeneration, neurologic decline and cardiovascular disease. It also limits our capacity for cellular repair. By supplementing our levels of NAD+, researchers think that we may be able to fight these natural declines and stay happy and healthy longer.
Adding NAD+ can treat a variety of ailments, including:
- Chronic fatigue syndrome
- Drug addiction
- Neurodegenerative disorders such as multiple sclerosis
- Cognitive function after traumatic brain injury (TBI)
- Cognitive function related to Alzheimer’s and memory loss
NAD and Fertility
There are a variety of treatments intended to boost fertility, with varying levels of success. However, many of these treatments may not only be invasive but are also often expensive. One of the most exciting new developments in the field of fertility treatment is NAD+ supplementation. NAD+ is already well-known for its anti-aging properties, and it seems that it can also be effective in improving fertility
How Does Aging Affect Fertility?
One of the key factors for a successful pregnancy is the quality of a woman’s eggs. While women have a set number of eggs that decrease as they age, the quality of the eggs also decline at the same time. This decline is significantly faster after a woman’s mid-30s, and egg cells do not renew—they age just like the woman herself. As they age, they become more genetically unstable due to various environmental and lifestyle factors, such as toxins and carcinogens. This may increase the chances of DNA damage or other defects that can contribute to infertility in women or congenital defects in newborns.
Egg quality is becoming a major issue as women choose to have children later in life. Even the best fertility treatments and in vitro fertilization cannot improve egg quality or reverse aging-related egg defects. Many women often have to use eggs from a younger donor, which may not be ideal for a number of reasons.
Can NAD+ Supplements Help with Fertility?
NAD is a co-factor in many of the key processes within human cells. It is crucial for maintaining healthy cells and the cell’s ability to turn nutrients into energy. NAD is also vital for cell resilience and repairing DNA damage. However, NAD levels in the body also drop with age, lowering to around half of the peak amount. This deficiency may explain many of the effects of aging, including lowered fertility rates.
NAD may be able to address the issue of egg quality, helping the egg cells repair DNA damage and
improving fertility rates as a result. This is the only type of therapy that has the potential to do this, meaning it could be an incredibly effective form of fertility treatment. There are very promising results from studies being conducted now, with many concluding that increased NAD levels can improve the quality of eggs.
Can you take too much NAD?
In much higher levels, it can have some serious side effects such as nausea, brain fog, diarrhea, abdominal pain, gout and itching. Human studies have shown that it is safe to use in dosages of 1,000 to 2,000 mg.
When should I take NAD morning or night?
NAD+ is shown to regulate Circadian rhythms (it’s the body’s mechanism that regulates when you are awake and when it’s time to go to sleep). For this reason, we always recommend taking NMN in the morning.
How long does it take for NAD to work?
Dietary plans can include vitamin-rich foods to boost dopamine and can produce NAD in the brain. Most patients need roughly 6 to 10 days of infusion to feel effects.
How can you increase NAD levels in the body?
NAD+ supplements are one of the easiest and most convenient ways of doing this, as most NAD+ supplements come in tablet form and simply need to be taken a couple of times a day. These supplements may not only help with fertility, as improved NAD levels also have other benefits:
- Increased physical energy
- Better cognitive performance
- Improved sleep quality and recovery
- Improved short-term memory
- Increased metabolism
- Anti-aging properties
- Lowered blood pressure